(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol - Names and Identifiers

Name	puerarin
Synonyms	puerarin Puerarine purerarin PSYCHOSINE Kudzu Extract PUERARIAROOT.P.E PUERARIN EXTRACT 8-GLUCOSYLDAIDZEIN Kudzu Root extract 8-glucosyldaidzein Pueraria root flavone DAIDZEIN-8-C-GLUCOSIDE Daidzein-8-C-glucoside 7-hydroxy-3-(4-hydroxyphenyl)- 7,4'-Dihydroxy-8-C-glucosylisoflavone 4',7-Dihydroxy-8-C-Glucosylisoflavone 7,4'-Dihydroxy-8-C-Glucosylisoflavone 1-n-Dodecylazacycloneptan-2-one Nizatidine 4H-1-Benzopyran-4-one,8-β-D-glucopyranosyl- 1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]hexitol 7-HYDROXY-3-[4-HYDROXYPHENYL]-1-BENZOPYRAN-4-ONE 8-[BETA-D-GLUCOPYRANOSIDE 7-hydroxy-3-[4-hydroxyphenyl]-1-benzopyran-4-one 8-[beta-D-glucopyranoside 8-beta-D-Glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 8-(Beta-D-Glucopyranosyl-7-Hydroxy-3-(4-Hydroxyphenyl)-4h-1-Benzopyran-4-One 4H-1-Benzopyran-4-one, 8-beta-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)- (1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol (1xi)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol 7-Hydroxy-3-(4-Hydroxyphenyl)-8-[(2s,3s,4r,5r,6r)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Chromen-4-One
CAS	3681-99-0
EINECS	609-296-1
InChI	InChI=1/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21?/m1/s1
InChIKey	HKEAFJYKMMKDOR-NCHCSYJDSA-N

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol - Physico-chemical Properties

Molecular Formula	C21H20O9
Molar Mass	416.38
Density	1.614±0.06 g/cm3(Predicted)
Melting Point	187-189°C
Boling Point	688.0±55.0 °C(Predicted)
Flash Point	245.1°C
Water Solubility	Soluble in DMSO or DMF. Slightly soluble in water or ethanol
Solubility	Dissolved in methanol, slightly soluble in ethanol, slightly soluble in water, insoluble in chloroform or ether.
Vapor Presure	7.06E-20mmHg at 25°C
Appearance	White needle crystal
Color	White to Off-white
Maximum wavelength(λmax)	['303nm(MeOH)(lit.)']
BRN	64198
pKa	6.46±0.20(Predicted)
Storage Condition	2-8°C
Refractive Index	1.719
MDL	MFCD00076007
Physical and Chemical Properties	White needle-like crystals, heat soluble in water, methanol, ethanol, insoluble in ethyl acetate, chloroform, benzene, from Pueraria root.
Use	Vasodilator for the treatment of coronary heart disease, angina pectoris and other diseases

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol - Risk and Safety

Risk Codes	R11 - Highly Flammable R34 - Causes burns
Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition.
WGK Germany	3
RTECS	UO5216000
FLUKA BRAND F CODES	10
HS Code	29389090

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol - Reference Information

Plant source:	Pueraria lobata
update date:	2022/11/12 10:05:38
introduction	puerarin, also known as puerarin flavone, is a natural isoflavone carbon glycoside and is the key ingredient for puerarin to exert its medicinal effect. Puerarin has the effects of lowering blood sugar, regulating blood lipids, protecting blood vessels, resisting oxidative stress, resisting infection, improving insulin sensitivity index, etc., and has fewer adverse reactions. It is known as "phytoestrogen" and is clinically used to treat cardiovascular and cerebrovascular diseases, cancer, Parkinson's disease, Alzheimer's disease, diabetes and diabetes complications.
uses	pueraria root crude extract and puerarin have regulatory effects on proliferation inhibition, apoptosis induction and cell cycle of liver cancer cell SMMC-7721, and can inhibit its growth to varying degrees, and pueraria root crude extract can promote apoptosis of SMMC-7721 cells. Puerarin can promote the proliferation of human T lymphocytes γδT and increase its killing activity, while the proliferation of γδT cells may be related to the Bcl-2 expression of puerarin-activated P-ERKl/2 signaling pathway and anti-apoptotic protein, and the improvement of γδT cell SMMC-7721 killing activity on hepatocellular carcinoma cells may be related to the expression of granzyme B, perforin and CD107a in γδT cells. [Pharmacological effects] can be used for adjuvant treatment of coronary heart disease, angina pectoris, myocardial infarction, retinal artery and vein occlusion, sudden deafness and ischemic cerebrovascular disease, viral myocarditis in children, diabetes, etc. Effects on the cardiovascular system
pharmacological action	kudzu root is the PuerariathomsoniiBenth of leguminous plant kudzu vine (kudzu kudzu). Or Puerarialobata(Willd.)Ohwi. The root. Sweet, pungent, cool in nature. Return to spleen, stomach and lung meridian. It has the effects of relieving muscle and deheating, penetrating rash, promoting body fluid and quenching thirst, promoting yang and stopping diarrhea, dredging meridians and activating collaterals, and relieving alcohol and poison. It is often used in exogenous headache, fever, neck back pain, measles impermeability, thirst, thirst, heat dysentery, diarrhea, dizziness, headache, stroke, hemiplegia, chest pain, and alcohol injury. Pueraria lobata contains a variety of effective ingredients, mainly puerarin. Puerarin Chinese alias 8-beta-D-grape pyranose -4 ', 7-dihydroxyisoflavone. Modern studies have shown that puerarin has a good effect on sudden deafness and cardiovascular and cerebrovascular diseases. Used to dilate blood vessels and improve blood circulation; reduce myocardial oxygen consumption and inhibit cancer cells; increase coronary flow and adjust blood microcirculation; treat sudden deafness at all ages; reduce the risk of cardiovascular and cerebrovascular diseases. As people conduct in-depth research on the pharmacological effects of Pueraria lobata, various foods and drugs processed as raw materials are widely praised by people at home and abroad. puerarin can remove free radicals in the body to varying degrees, reduce lipid peroxidation damage, and improve the activities of antioxidant enzymes in the body, such as SOD, glutathione peroxidase and catalase. puerarin can improve immunity, improve microcirculation, expand blood vessels, increase coronary flow, reduce blood pressure, slow down heart rhythm and reduce myocardial oxygen consumption without obvious negative inotropic effects. It also has the effects of anti-thrombosis, improving high-density lipoprotein, anti-vasospasm and reducing platelet accumulation.
treatment of diabetes	puerarin can treat diabetes by lowering blood sugar concentration. puerarin can up-regulate insulin receptor substrate IRS-1 and insulin-like growth factor IGF-1 protein, and at the same time promote the expression of insulin receptor InsR and peroxisome proliferator activated receptor PPARα, thus achieving the purpose of reducing blood sugar and treating diabetes. In addition, puerarin can also inhibit the activity of α-glucosidase, thereby reducing blood sugar concentration and achieving the purpose of treating diabetes. Studies have found that puerarin drugs can improve the body's sensitivity to insulin in patients with type 2 diabetes. Puerarin drugs can weaken insulin resistance and treat diabetes. Puerarin can also inhibit the production of TNF-α in plasma, improve the body's sensitivity to insulin levels, and reduce blood sugar levels. In addition, the application of puerarin in diabetic retinopathy can help reduce the blood flow resistance of the ophthalmic artery, accelerate the blood flow speed, promote the expansion of the muscle artery, and reduce local thrombosis, which has a preventive effect on diabetic retinopathy. Puerarin also has a therapeutic effect on gestational diabetes.

Last Update：2024-04-09 02:00:08

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol

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Mobile: +86-17551318830
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Hefei TNJ Chemical Industry Co.,Ltd.

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CAS: 3681-99-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840

Wechat: 0086 189 4982 3763
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Product List: View Catalog

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Product Name: Puerarin Visit Supplier Webpage Request for quotation
CAS: 3681-99-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Changsha Staherb Natural Ingredients Co., Ltd.,

Spot supply

Product Name: Puerarin Visit Supplier Webpage Request for quotation
CAS: 3681-99-0
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
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(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol

puerarin

CAS: 3681-99-0

Molecular Formula: C21H20O9

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol - Names and Identifiers

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol - Physico-chemical Properties

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol - Risk and Safety

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol - Reference Information

Supplier List

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol Request for Quotation

puerarin

CAS: 3681-99-0

Molecular Formula: C21H20O9

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol - Names and Identifiers

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol - Physico-chemical Properties

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol - Risk and Safety

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol - Reference Information

Supplier List

(1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol